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Hesperidin is a chemical found exclusively in plant-based foods, especially citrus fruits. Hesperidin is considered a bioflavonoid, also called flavonoids, which are a group of pigments that give fruits and flowers some of their bright colors and aroma.

Hesperidin is found naturally in foods and is sold as a dietary supplement. People use hesperidin for medicinal purposes as well, according to WebMD.

Hesperidin can decrease pain and inflammation; it also is beneficial for healthy blood vessels. Hesperidin's effects can be beneficial for conditions from nosebleeds to hemorrhoids.

Not all types of physical activity are suitable for everyone. Users take training advice at their own personal risk.


Hesperidin is a water-soluble bioflavonoid that occurs naturally in citrus fruits, such as lemons and oranges. The peels and membranes have the most hesperidin. Fruit juices that contain a lot of pulp are rich sources of hesperidin as well, according to Bodybuilding.com. Hesperidin is sold... more

Hesperidin is a water-soluble bioflavonoid that occurs naturally in citrus fruits, such as lemons and oranges. The peels and membranes have the most hesperidin. Fruit juices that contain a lot of pulp are rich sources of hesperidin as well, according to Bodybuilding.com.

Hesperidin is sold as a supplement and used as medicine. It has antioxidant properties, meaning that it combats and neutralizes harmful free radicals. It has also been shown to help people with a range of medical conditions, from the tendency to bruise easily to leg ulcers.

The human body cannot make hesperidin and therefore needs it and other bioflavonoids from diet or supplements. Bioflavonoids are very important and are therefore referred to collectively as vitamin P, though they are not actually vitamins, according to LiveStrong.com.

Natural Sources

Eating foods like oranges provides the body with natural hesperidin. Some vegetables are also sources of this nutrient. Broccoli, green peppers and yellow peppers are sources of hesperidin. Whole grains contain the nutrient as well, according to LiveStrong.com.

Even though some vegetables and grains have hesperidin, dietary supplements are made from citrus fruit extracts.

Heart and Vascular Benefits

Hesperidin primarily works by decreasing inflammation and pain, and by helping blood vessels to function better, according to RXList.com. Studies on animals demonstrated that hesperidin has vasoprotective effects. Results showed that hesperidin increases HDL "good" cholesterol and lowered LDL "bad" cholesterol.

Human studies have shown that hesperidin provides several benefits. According to Bodybuilding.com, human trials reveal that hesperidin can protect and benefit the heart by lowering blood pressure values, lowering homeocysteine concentrations and raising folate levels.

Europeans use hesperidin as treatment for vascular conditions, varicose veins and for capillary health.


Studies show hesperidin may have anti-cancer benefits. In addition to hesperidin's antioxidant effects, it helps keep the immune system strong and supports cell integrity. Hesperidin may exert a protective effect against skin cancer, colon cancer, urinary cancer and esophageal cancer.

A review of 12 cancer studies found that people who ate the greatest amounts of dietary bioflavonoids had a lower risk of lung cancer than people who consumed fewer bioflavonoids, according to the New York University Langone University.

Joints and Skin

Along with vitamin C, hesperidin assists with collagen production and structure function. Collagen is a collection of proteins used in skin and connective tissue, including the ligaments and tendons that connect bones to bones and bones to muscles.

In this way, hesperidin promotes healthy joints. Collagen helps keep skin free of wrinkles and improves tone.


Hesperidin can be beneficial for athletes and regular exercisers. Taking hesperidin helps speed exercise recovery and decreases inflammation caused by working out.

Recoverying more quickly from exercise allows people to work out more often and with less discomfort.


WebMD states that hesperidin is possibly effective for hemorrhoids, when taken with another bioflavanoid called diosmin.

Taking these two supplements together significantly improves hemorrhoid symptoms. It can also prevent recurrence of hemorrhoids.

Leg Ulcers

Leg ulcers are typically due to poor circulation, according to Net Doctor. Ulcers are breaks in the skin that do not heal.

Hespiridin, along with diosmin and compression dressings, can help small ulcers to heal if they are caused by circulation problems, according to %WebMD% http://www.webmd.com/vitamins-supplements/ingredientmono-1033-HESPERIDIN.aspx?activeIngredientId=1033&activeIngredientName=HESPERIDIN

Arm Swelling

Breast cancer surgery sometimes causes lymphedema. Lymphedema causes swelling of the arms.Hesperidin may decrease swelling, according to WebMD.

Bruising and Nosebleeds

Certain people possess fragile capillaries. This can predispose them to bruising easily. The New York University Langone University reported that a study involving 96 people with fragile capillaries who took hesperidin and diosmin demonstrated reduced symptoms of capillary fragility, including nosebleeds and bruising.

Another study conducted in the 1960s discovered that citrus bioflavonoids and vitamin C reduced bruising in college athletes.


Hesperidin comes with different recommended intake amounts depending on the purported usage. According to RXList.com, taking 150 milligrams of hesperidin along with 1,350 milligrams of diosmin two times per day for four days and then 100 milligrams of hesperidin with 900 milligrams of diosmin two times per day for three days may be beneficial for hemorrhoids located in the anus.

Hesperidin can also help prevent hemorrhoids from coming back. Recommended intakes for prevention of hemorrhoids in the anus is 50 milligrams of hesperidin along with 450 milligrams of diosmin two times a day for three months.

To treat leg ulcers, the recommended intake is 100 milligrams of hesperidin along with 900 milligrams of diosmin each day for two months.

A hesperidin supplement called hesperidin methyl chalcone may reduce hot flashes when the recommended intake is used. This supplement combines a hesperidin complex with vitamin C and hesperidin methyl chalcone.

According to Drugs.com, taking this supplement may reduce hot flashes by working to maintain vascular integrity and to increase capillary strength.

As little as one tablet per day can help hot flashes. However, Drugs.com suggests taking two tablets three times daily following meals, then gradually decreasing amounts after one month to help figure out how much an individual needs.

Side Effects

Hesperidin is likely safe to use for fewer than three months, according to RXList.com. However, WebMD states that it is possibly safe for use up to six months.

Hesperidin may cause side effects, such as:

  • Abdominal pain
  • Diarrhea
  • Headache
  • Upset stomach


Hesperidin is contraindicated for use by pregnant or breastfeeding women, according to RXList.com.

There has not been enough testing to determine that the supplement is safe, but also there are no studies to indicate that it is a hazard.




  • http://www.med.nyu.edu/content?ChunkIID=21574
  • http://www.rxlist.com/hesperidin/supplements.htm
  • http://www.bodybuilding.com/fun/southfacts_hesperidin.htm
  • http://www.drugs.com/drp/hesperidin-methyl-chalcone.html
  • http://www.webmd.com/vitamins-supplements/ingredientmono-1033-HESPERIDIN.aspx?activeIngredientId=1033&activeIngredientName=HESPERIDIN
  • http://lpi.oregonstate.edu/infocenter/phytochemicals/flavonoids/
  • http://www.livestrong.com/article/342775-what-is-hesperidin-vitamin-p/
  • http://www.nlm.nih.gov/medlineplus/ency/article/000005.htm
  • http://www.netdoctor.co.uk/diseases/facts/footandlegulcers.htm


  • Side Effects
  • Other Names
  • Uses
Upset Stomach
Abdominal Pain
Bioflavonoid, Bioflavonoid Complex, Bioflavonoid, Concentrate, Bioflavonoid Extract, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Diosmetin, Diosmin, Flavonoid, Hesperidin Methyl Chalcone, Naringin, Narirutin, Neohesperidin, Nobiletin, Rutin, Tangeretin, Trimethylhesperidin-Chalcon
Chronic Venous Insufficiency
Joint Health
Recovery After A Workout
Skin Health
Speeds Healing Of Leg Ulcers
Varicose Veins
Arm Swelling