Aid Overall Health / Lose Weight

Diindolylmethane, or DIM, is a lipophilic oil-soluble compound that acts like an anticarcinogen in the body. DIM is a well researched lipophilic element that is found naturally in vegetables such as broccoli, cauliflower, kale, cabbage and Brussels sprouts.

DIM has been researched for over 40 years and has a number of benefits. However, DIM alone is not easily absorbed and DIM supplements were virtually useless until the University of California at Berkley found a mechanism of action that allowed DIM to be absorbed by the body.

In studies, only the type of DIM provided by the University of California at Berkley is used. This is true of all clinical studies using DIM, not just of studies done by UC at Berkley. It is important to note this distinction, as some supplements don’t have this patented combination, making them unbeneficial to the body.

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Diindolylmethane Combination The combination that you should be looking for is DIM complex with vitamin E TPGS, which is a lipid-based drug formulation. This is the patented formula that has been extensively studied and provides the highest level of absorption into the body. The good n... more

Diindolylmethane Combination

The combination that you should be looking for is DIM complex with vitamin E TPGS, which is a lipid-based drug formulation. This is the patented formula that has been extensively studied and provides the highest level of absorption into the body.

The good news is that DIM is a lipophilic that has been studied in both animal and human studies. This is beneficial to you because animal studies have very little credence in the medical community. However, successful human studies offer proof of what DIM has to offer to the overall health of your body.

Clinical studies show that DIM activates the immune response system. As a result, your body benefits in a number of different ways.

Diindolylmethane and Cancer

Quite possibly the most important element of DIM is it’s function as an anticarcinogen. An anticarcinogen is basically an anti-cancer chemical that offers benefits against cancer in a number of different ways.

  • First of all, anticarcinogens reduce your risk of cancer. This is a reduction for any type of cancer, although there are some specific cancers that have been studied in clinical settings.
  • Secondly, anticarcinogens work in your body to reduce the affect of cancer on your body, if you already have cancer. Not only can it prevent additional cancer cell growth, it can also help to kill some of the existing cancer cells, aiding in sending the cancer into remission.
  • Thirdly, anticarcinogens deactivate carcinogens so that your body builds its own defense against cancer.

Cancer studies using DIM in cancer patients have shown positive results (a reduction of cancer cells, or cancer going into remission) for prostate cancer, breast cancer, and cervical cancer.

In addition, anticarcinogens aid in helping balance out the hormones in women going through menopause while reducing the risk of cancer in these women. Interestingly, DIM acts as an estrogen but at the same time prevents the onset of estrogen effects.

What this means is that when you take estrogen supplements, you are actually increasing your chances of cancer. However, DIM doesn’t increase your risk of cancer, it reduces your risk. It is unclear how this happens, but there have been no clinical trials where a woman taking DIM had any estrogen effects while taking the supplement.

Recent studies show that DIM aids in the prevention and elimination of cervical dysplasia. Cervical dysplasia is not cancer, but it is considered a precursor to cancer.

Diindolylmethane Benefits Beyond Cancer

DIM has also been shown to help people reduce weight. This is because DIM is a lipophilic oil-soluble compound. That means that DIM is able to dissolve fat. That doesn’t mean that all of your fat is dissolved when you take DIM, you still need to eat healthy and exercise while taking DIM supplements.

In addition, DIM can increase insulin sensitivity. This means that as a diabetic, you could benefit from taking DIM. If you are insulin dependant, you need to speak to your doctor before taking DIM to ensure that your increased sensitivity doesn’t cause problems during your treatment.

In menopausal women, DIM helps to reduce the sensitivity of a woman’s breasts. It also acts as a mood stabilizer preventing mood swings. DIM has also showed benefits as an anti aging compound. It prevents oxidation of the cells and promote healthy skin.

In new, less developed studies, DIM is being tested as a hair loss deterrent. Some supplements already sell it in this capacity; however, these test are in test tube and animal study phases and not currently being used in clinical trials.

Diindolylmethane Side Effects and Interactions

DIM is well tolerated and the only reported side effect of using DIM is headaches. There are no other reported side effects and this is a supplement that has been around for a number of years.

In addition, DIM is easily introduced to the body via food. However, if you aren’t a fan of Brassica vegetables, then a supplement is an excellent alternative.

You do need to be aware, however, that although DIM doesn’t have any apparent side effects, it can interact with some medications. In this case, DIM can prevent medications that depend on the liver for break down and disbursement from working as effectively. That is why it is important to talk to your doctor if you are taking any medications before you start taking DIM.

In fact, most experts agree that no matter what the reason is you are taking a DIM supplement, if you have any medical conditions you should talk to your doctor first.  DIM has been tested on women and children in clinical trials, however, your doctor is the best person to determine if DIM is right for you in these situations.

Diindolylmethane Supplements

If you want the most effective form of DIM supplements, then you need to look for supplements that say encapsulations on them. This is the type of DIM that is used in clinical trials.

You need to be aware, however, that this form of DIM is more expensive than any other form, costing as much as $72 for a bottle. You can purchase less expensive DIM supplements that use vitamin E as an assistant in the body absorbing the DIM, however, it will not provide the same absorption levels as the encapsulations form will.

This does not mean that you cannot get a benefit from using DIM without encapsulations; however, the benefit won’t be as great. Because DIM is well tolerated in higher doses, you might consider going off label for dosage amount. Talk to your doctor before you take that course of action.

In addition, numerous products combine DIM with other vitamins and fillers. This is not uncommon and many studies show that DIM is an excellent supplement to combine with isoflavones , among other things.

In most cases, DIM products are available in capsule form. However, some supplement companies combine them in protein shakes and powders. You need to understand that there are no studies to show the benefit of DIM in these combinations. In all likelihood, they are sold this way because of the proven use of DIM in obesity.

You will find that DIM is commonly marketed to menopausal women, as an anti-cancer supplement, and even as a testosterone booster in men. Because it doesn’t have the estrogen effect, it is assumed that it will reduce the amount of estrogen levels in men and increase testosterone. This is still an unproven assumption at this point in time.

Use the supplement finder provided to find the best source of Diindolylmethane now!


  • Side Effects
  • Other Names
  • Uses
Diindolymetano, DIM, 3,3'-Diindolylmethane
Cancer Prevention
Cancer Treatment
Cervical Dysplasia
Skin Health