Aid Overall Health

L-Proline is a non-essential amino acid. What this means is that your body synthesizes it naturally and you do not need to get it from food or from supplements. In fact, with the exception of the elderly and some rare conditions, your body produces all of the L-Proline that you need.

Even though you don’t need to get L-Proline from foods, it does appear in meat products as well, more specifically red meat. If you are one of the few people who can’t produce enough of this amino acid, then you may get the boost that you need from eating meat.

Despite the fact that the body makes plenty of L-Proline, there are dozens of different L-Proline vitamin supplements available. Often it is combined with L-Lysine, which is an amino acid that the body cannot produce on its own.  

Not all types of physical activity are suitable for everyone. Users take training advice at their own personal risk.


L-Proline Health Benefits L-Proline was discovered in the early 1900s and the benefits to the body were almost immediately obvious. L-Proline helps to maintain the body’s connective tissue. In addition, if the connective tissue is damaged, then L-Tryptophan aids in its repair. Some stu... more

L-Proline Health Benefits

L-Proline was discovered in the early 1900s and the benefits to the body were almost immediately obvious. L-Proline helps to maintain the body’s connective tissue. In addition, if the connective tissue is damaged, then L-Tryptophan aids in its repair.

Some studies show a connection between the body’s levels of L-Proline and its ability to heal wounds and cuts on the surface skin. In addition, L-Proline is believed to aid in the healing of muscle tissue when it is damaged as well.  Studies are currently being conducted to prove or disprove this benefit.

L-Proline has been directly linked to the production of collagen. You may think of collagen as something that keeps your skin looking young, but the truth is that collagen is a substance found everywhere in the body, even the bones and the eyes.

Recent studies of L-Proline have determined that it is an excellent source for the reduction of hypertension. You can read more about this in the American Journal of Hypertension.

Of course the downside is that if you have low blood pressure already or are on blood pressure medication, your blood pressure could drop dangerously low. You should consult your doctor before adding L-Proline to your supplement regimen if you have low blood pressure.

L-Proline Side Effects

If you buy L-Proline, you will find that most manufactures declare that L-Proline is non toxic and has no side effects. Unfortunately, this just isn’t true- side effects are rare, but they do exist.

The first area of consider is stomach issues, more specifically nausea and loss of appetite. In most cases, these side effects occurred because too much L-Proline was used and this caused some toxicity. In addition, toxicity has been discovered in individuals who have taken L-Proline supplements for extended periods of time.

Another serious side effect has developed in people with liver disease, those who are malnourished and those who have a family history of neurological disorder.  This side effect is neurological problems. If you have any of these conditions, then you should not take L-Proline.

In addition, if you have high levels of lactic acid in your blood, then you should not take L-Proline either. That is because your body cannot properly break down the L-Proline and your body essentially gets an overdose. This can lead to the onset of hyperprolinemia, a disease which causes cognitive dysfunction.

One positive side effect of L-Proline is its ability to lower blood pressure. As mentioned above, this means if you are on blood pressure medication or are prone to low blood pressure naturally, then you should avoid taking L-Proline. These supplements are not regulated by the FDA.

L-Proline and the Elderly

While most people produce enough L-Proline that they don’t need to take supplements, if you are over the age of 65 you will want to speak to your doctor about testing your L-Proline levels. Some studies have linked some of the body’s degradation during the aging process to the reduction of the production of L-Proline in the body.

There is some speculation about the extent of the impact of lower L-Proline levels and further studies are needed to determine just how extensively L-Proline can affect the body. Until then, in most cases there is no harm in taking a small dose of L-Proline as a supplement as you age.

L-Proline the Bottom Line

Quite truthfully, you really don’t need L-Proline supplements unless you actually have a deficiency. When taking supplements, studies do not show any additional health benefits in terms of collagen production, the health of connective tissues or increased healing of wounds.

If, however, you face hypertension issues, then L-Proline supplements may help. In fact, certain blood pressure medications now contain L-Proline as an active ingredient.

Use the supplement finder to learn about other amino acids and their benefits to your body!


  • Side Effects
  • Other Names
  • Uses
Loss Of Appetite
Contraindicated For Certain Medical Conditions
Neurological Problems
Bovine Casein Hydrosylate, C12, C12 Peptide, C12 Peption, Calcium Caseinate, Casein Decapeptide, Casein-derived Peptide, Casein Hydrosylate, Casein Peptide, Casein Phosphopeptide, Casein Protein Extract, Casein Protein Hydrosylate, Casein Tripeptide, Casein Tryptic Hydrolysate, Caséinate, Caséinate de Calcium, Caséine de Potassium, Caséine Hydrolysée, Concentré de Caséine Hydrolysée, Cysteine Milk Peptide, Extrait de Protéine de Caséine, Extrait de Protéine de Lait, Hydrolysed Casein, Hydrolyzed Casein, Hydrolyzed Casein Concentrate, Hydrolyzed Lactalbumin, Hypotensive Peptides, Isoleucyl-Prolyl-Proline, Lactalbumin Hydrolysate, Lactalbumine Hydrolysée, Lactotripeptide, Milk Protein Extract, Milk Protein Hydrosylate, Peptide C12, Peptide Dérivé de la Caséine, Peptides de Caseine, Peptides de Caséine, Peptides Hypotenseurs, Péptidos de la Caseína, Potassium Caseinate, Protéine de Lait Hydrolysée, Sodium Caseinate, Sour Milk Extract, Sour Milk Peptides, Tripeptide de Caséine, Valyl-Prolyl-Proline
Collagen Production
Connective Tissue Health
Muscle Repair
Wound Healing